Rheumatoid arthritis (RA) is a chronic autoimmune condition characterised by persistent joint inflammation, pain, and potential joint deformity. Methotrexate (MTX) is commonly prescribed as a first-line treatment; however, not all patients achieve optimal results, and some experience adverse effects. Emerging research suggests that adjunctive therapies, such as medical ozone, may enhance treatment efficacy and patient outcomes.pubmed.ncbi.nlm.nih.gov
Understanding the Study
A study published in the European Journal of Pharmacology explored the effects of combining medical ozone therapy with methotrexate in patients with RA. The clinical response was assessed using several parameters:pubmed.ncbi.nlm.nih.gov+1ossigenoozono.it+1
- Disease Activity Score 28 (DAS28): A measure of RA disease activity.researchgate.net+2onlinelibrary.wiley.com+2onlinelibrary.wiley.com+2
- Health Assessment Questionnaire Disability Index (HAQ-DI): Evaluates patients’ functional ability.
- Anti-Cyclic Citrullinated Peptide (Anti-CCP) levels: Indicators of autoimmune activity.pubmed.ncbi.nlm.nih.gov
- Acute phase reactants and oxidative stress markers: Assess inflammation and cellular oxidative balance.
Key Findings
The combination of MTX and ozone therapy yielded notable improvements:pubmed.ncbi.nlm.nih.gov
- Reduced Disease Activity: Significant decreases in DAS28 scores indicated lowered RA activity.onlinelibrary.wiley.com+2pubmed.ncbi.nlm.nih.gov+2onlinelibrary.wiley.com+2
- Improved Functional Ability: HAQ-DI scores showed enhanced patient mobility and daily functioning.pubmed.ncbi.nlm.nih.gov
- Lowered Autoimmune Markers: Anti-CCP levels were significantly reduced, suggesting decreased autoimmune response.pubmed.ncbi.nlm.nih.gov
- Enhanced Oxidative Balance: Increased antioxidant levels and reduced oxidative stress markers were observed, indicating improved cellular health.
Importantly, no adverse effects were reported, underscoring the safety of this combined approach.
Implications for RA Management
These findings suggest that integrating medical ozone therapy with standard methotrexate treatment may offer enhanced benefits for RA patients. By reducing inflammation, improving immune regulation, and bolstering cellular antioxidant defences, this combination could lead to better disease control and improved quality of life.pubmed.ncbi.nlm.nih.gov
At Flow and Glow, we’re committed to providing innovative, evidence-based therapies. Our medical ozone treatments are designed to complement existing RA management plans, aiming to optimise patient outcomes.
For more information, view the full study here:
https://pubmed.ncbi.nlm.nih.gov/27450487/